Apr 3, - Dear Alice,. Every time I have an orgasm (alone or with a partner) I have intense feelings of guilt. I was not brought up in a religious household. Jan 16, - She explained that it comes down the explosion of hormones in the body after sex, including endorphins, oxytocin and prolactin. “Having sex is a hugely intimate act and an orgasm releases lots of wonderful feel-good bonding hormones.