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The most important hormone involved in controlling sperm production is a by a cocktail of hormones, in particular DHT, the production of which is controlled by. Within the brain, the hypothalamus and anterior pituitary control sperm production. The hypothalamus secretes gonadotropin-releasing hormone (GnRH), which acts on the anterior pituitary gland, stimulating it to release follicle stimulating hormone (FSH) and leutinizing hormone (LH).